What I should do, what I can do

Mar. 31st, 2026 01:41 am
twistedchick: watercolor painting of coffee cup on wood table (Default)
[personal profile] twistedchick
I should be writing the Substack column, or at least trying. But I have no words right now. The words are just ... missing.

There is too much news going on, and not enough that's new. They weren't kidding about calling it a 'flood' of information, designed to bury us under extraneous crap. I can deal with that; I do deal with it, sorting through it to newsblog on FB as I've done the past few years. But this week nothing is standing out and waving for me to write about it. So much is either at a standstill or just not at a point that has changed. And what I need is something that is changing, so I can look at before and after or alternatives.

I am encouraged by the 9 million or so people who came out during No Kings, though the statistic is muddled -- I have seen it attributed to worldwide protests that day as well as to in-country protests, which is not helpful. But still, 9 million. And so many small places in Red states with sizeable crowds protesting -- and on my side of the street, too. So encouraging.

It just feels as if the Winter of our Discontent is still blowing winds. The only Son of York on the horizon is Jack Schlossberg, grandson of JFK and definitely a Son of York as he's New York born and bred. I do support him and if I still lived in that state would be out stumping for him -- but he's running for a Congressional seat, and that is not going to be enough to overturn the Joker in the Oval.

But it's a start. I can use a start.

(no subject)

Mar. 30th, 2026 09:13 pm
aurumcalendula: reflection of Vinnie from Wiseguy in a shattered mirror (fractured)
[personal profile] aurumcalendula
Apparently Wiseguy did have at least one queer person among its cast and crew (Joe Dallesandro played Patrice) so now I'm kinda curious if he's ever mentioned if he thought any of the queer subtext was intentional.
conuly: (Default)
[personal profile] conuly
And I have some thoughts.

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******************


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tsuki_no_bara: (Default)
[personal profile] tsuki_no_bara
so it's been a while, huh. can i blame it on the fact that it might finally actually be spring out here? a week ago i woke up and there was snow on the ground and then it was cold and then it warmed up a bit and now i think it's spring for real. yay.

also i caught a cold last week but seem to be on the mend which is good because i'm going to atlanta on wednesday to spend passover with the cousins and the last thing i want to bring with me is a headcold. i mean, just having to get on a plane with all that congestion is bad enough, nevermind potentially giving it to someone. my cousin with the twins who are old enough to be adults, the boytwin is in a band - have i mentioned this? boys go to jupiter, highly recommended - they played around here on thursday and i did not go because a. i felt crappy but more importantly b. i did not want to feel crappier. it was sold out! which is very exciting but at the same time i'm bummed i couldn't go.

also also my car is still in the shop because they fixed it and then something else went wrong and they're trying to figure out what it is. sigh.

other things worth mentioning:

went to a book fair with one of the admins m and one of the admins a (plus admin a's hubs) from work and bought a couple of bookmarks and a magnet of tomatoes making faces. and a book, ok (the space between worlds, by micaiah johnson). sunny, warmish, a good day to hang with some of my fellow admins under non work circumstances.
watched the immortal man, the peaky blinders movie, which felt oddly detached from the series (altho there were a bunch of returning characters) but i think you kind of needed to have seen the show to fully understand what was going on. not sorry i saw it, also not sorry i didn't see it in a theater. spoiler! )
attended approximately half a million meetings with my fellow admins over what we want to happen now that the admin manager's gone even tho it's not actually our decision. we just kept chewing on the same ideas over and over until finally one of the admins n pointed out that we can talk all we want but if hq wants [whatever] then we're getting [whatever]. they're going to replace the admin manager with three "team leads" - all admins - and we've seen the job description but no one's been asked to do it yet so who knows what's going on.
saw how to make a killing with my sister and it was fine mostly because i like margaret qualley (altho she played an awful person) and some of the killings are inventive. i think glen powell is overrated tho.
watched the first couple episodes of wonder man and liked it! super curious about the super powers.
watched the entirety (minus the last episode) of paradise which i also like! altho it can be a really hard watch and i have a lot of questions about the worldbuilding.
met [livejournal.com profile] tamalinn for lunch and had mac&cheese which was yummy and extremely comforting but could have used more cheese. altho let's be honest - even the cheesiest mac&cheese could use more cheese.
curled a lot, made some decent shots (last week my last two shots were perfect) and more not-so-decent shots, as per usual. last night was the last game which means i need something else to do with my sundays besides talk to the family unit and go to the grocery store.

because it's almost passover i must share the story of the house of maqswel haggadah for the jewish trek fan(s) in your life. it's less a haggadah and more the klingon flavored story of one. (there's an excerpt on amazon if you're curious.)

japan has an interesting way to combat loneliness for folks who live alone - yogurt delivery women. yes, really.

there's a world championship cheese contest which honestly should not surprise anyone. this year's winner was a dutch gouda. a goud gouda. :D

400k kitkats were stolen in europe en route to poland from italy. the whole truck just... vanished. poof. someone is going to have an absolutely insane crispetty chocolatey easter.

(no subject)

Mar. 30th, 2026 08:32 pm
blotthis: (Default)
[personal profile] blotthis
We're going to try our best, sport. CMAT's Euro-Country for [personal profile] littlerhymes  and Rosalía's Lux, for same and [personal profile] recognito .

Both these albums are full of incredible musical hybrid vigor. That's not a fair use of the term, as plenty of genre mashups are bad. These are not. These are so, so good. I'm grateful for the chance to talk about both, because I love them. I haven't done much research into their making, or even CMAT and Rosalía themselves, and I know next to nothing about music theory so my understanding of both albums is limited, I just really like them. 

I really like all of Euro-Country, but I think it might be easiest to talk it via two of my favorite songs on the album, "When A Good Man Cries," and "The Jamie Oliver Petrol Station." "Good Man" is a country song. It starts out with a country fiddle. It has a swing on it. Thompson croons twangily while taking herself to task for making a guy cry. And then, in the last third of the song, as the production thickens, she starts wailing, against her own voice in descant, Kyrie Eleison! It about knocked me out of my seat. In a country song? In a COUNTRY song? And it sounds absolutely at home. Even with the descant, which is pulled straight from Catholic mass, it sounds at home. It makes me crazy. What a fucking bridge. What a fucking ending. 

"The Jamie Oliver Petrol Station" is formed much in the same way, in that it builds from a clear thesis (she was at the Jamie Oliver Petrol Station, and god she hates him, but okay, don't be a bitch, the man's got kids and he wouldn't like this) to an inescapable musical explosion that blows my head off. But through all this she's doing crazy little things with rhythm--the FEAR and the FREEdom of BEing RE/leasedagain to FEEl svnTEEnagin--and also being really lyrically and logically hard to follow. She's got this incredibly clear thesis in the chorus, and then she keeps saying things like "Let me explain though," and "This is making no sense to the average listener," and "I'm still not explaining myself very well at all, let me try, let me try, let me try," and the whole thing's build suddenly is not about having a mantra about not being a bitch for no reason, it's about needing one, about feeling like you're flying apart at the seams where there aren't seams, and that's what the drums are doing. It rules. 

The whole album slides in and out of this kind of legibility to self and listener and illegibility to self and listener, and most of them are doing more than one thing at once. I really really want to see her live, if I can.

Rosalía, however, I've probably lost my chance. I could theoretically see her in a stadium sometime, but I don't really care for stadiums, so. Alas. This is a very tortured transition. Anyway! 

God I love Lux. The first time I listened to it, I stopped what I was doing by like the seventh song to just lie on my bed and cry due to being Artistically Moved. I looked up several publications' best albums of 2025, and I was shocked that it wasn't in almost anyone's top 10. I still don't know how that's possible. I can't listen to Lux and do other things because (Jenny Slate voice) it makes me too crazy.

Much has been made of the number of languages featured on Lux, (Rosalía sings in 13), but it's not just the languages. It's the styles. (puts face in hands and screams) Sorry. Sorry. I'm trying to be normal, I just keep listening to the tracks to have something clear to say and it's not actually helping----god. Okay. Okay. Okay. Okay. The range of this fucking album. It's got house music. It's got flamenco. It's got Italian arias. It's got Wagner. It's got spoken word. "Berghain," the one that Bjork is on, is the first track I heard and an incredible example. It comes right after the Italian aria and starts with an orchestra, like being slapped in the face. Then we get the Wagnerian chorus sung by an actual chorus, chanting in German that his fear is my fear, his rage is my rage. Like being slapped in the face. Then Rosalía comes on in possibly the highest soprano we've heard from her, and her descant is another slap. Bjork and Yves Tumor's entrances to the song are no less shocking and no less successful. It is an incredible feat of operatic maximalism and it is still somehow in conversation with a pop song. And it's not even my favorite song on the album!!!! 

I also love "La Perla," the slower, somehow-playful breakup ballad that follows "Berghain" and which is such a change of tempo and performance it's like what the FUCK; "Reliqia," a sparkling, somehow triumphant-sounding piece about losing pieces of yourself and becoming a holy relic; "Mio Christo Piange Diamanti," the aforementioned Italian aria she wrote at least in part for her classical-music-loving Grandmother, and in which she uses her ability to span trembling pianissimo to firm vibrato; "Dios Es Un Stalker," a chamber-pop-salsa depiction of love from the divine's watching eye... It's a good album, Brent. 
x95: Chibi artwork of the character An-An Lee from the video game Reverse: 1999. The Chinese characters read "下班" (R1999)
[personal profile] x95 posting in [community profile] fan_flashworks
Title: beyond a shadow of doubt that is memory
Fandom: Limbus Company
Rating: PG / General Audiences
Length: 100 words
Content notes: Spoilers for Canto VII: The Dream Ending, and Don Quixote (Limbus)’s backstory.
Summary: Here is the place she always longed for.

Story )

Daily Happiness

Mar. 30th, 2026 06:10 pm
torachan: arale from dr slump with a huge grin on her face (arale)
[personal profile] torachan
1. I have a decent familiarity with excel but only really use the basic functions and even though I know that there's formulas to do things faster, I usually feel like I don't have time to learn it, so I just do whatever it is manually. Well, today I finally decided the amount of time it would take to do it manually was not worth it and looked up how to use vlookup and now I know how to do at least this one thing and was able to get the work done really quickly.

2. I am working from home today and tomorrow, my last two days of work before vacation, both to save gas money and to reduce time spent around people and lower the risk of getting sick. Thankfully today I had a lot of deskwork to do (though it was made easier by #1 above) and tomorrow I've got meetings that can be done by web plus preparing stuff before vacation, so there's no need to go in.

3. Alex could not find the house keys we gave her last year when we went on our trip, so I went to a locksmith today to get an extra copy made. The front door lock is from when my parents bought the house in the early 70s (at the least) and when I got a copy made last year from a self-service kiosk it wasn't able to do it on the spot and had to have it mailed to me, but there was no time for that this time, so I went to Ace Hardware on Saturday but while their machine is not self-service, it is just a machine and of course the key was not in the machine so they couldn't make it. There are two nearby actual locksmiths but both are closed on the weekend, so I went first thing today and the guy was like wow, this is really old, but was able to make it in like a minute.

4. I think I'm fully used to my new mouse now and can confidently rec the Logitech MS Master 3S. I still miss the Microsoft Sculpt, but this is a pretty good replacement and once my work Sculpt dies, I'll likely buy one of these for work as well.

5. I used to be the sort of person who files my taxes in January as soon as I get my W2, but with the trust, we can't do that, because they need to provide us a document (K-1) and unlike work, which is required by law to give you your W2 by the end of January, they take their time and always get it to us by late March or even early April. I had asked if I could get it earlier this year since we'll still be out of town on April 15th, but they said they'd get it to us when they get it to us. I used to do my own taxes, but the K-1 is really difficult for me to figure out, so I have a tax preparer at H&R Block do it, and this is his third year doing our taxes now, so last year he said I should just submit everything online rather than coming in, so I submitted my W2 and filled out everything except the K-1 info and then told him I would get that to him as soon as possible, and they finally got that to us today, so I uploaded it to him and let him know. He said he should have it done by the end of the week, which means we will already be on our trip, so I downloaded their app to make doing the digital signature easier, but it should be pretty smooth. It's a huge relief to have that taken care of, though. I really wish the trust could get it to us sooner.

6. Suspicious Gemma is suspicious.

Looking for more people!

Mar. 30th, 2026 08:40 pm
midnight_heavenly_bodies: (Default)
[personal profile] midnight_heavenly_bodies posting in [community profile] addme
Name: C.K. or Chester

Age: 36, nearly 37, growing old mandatory, growing up optional

I mostly post about: Culture Club/Boy George & Jon Moss (my hyperfixation of 22 years and counting), Linkin Park, wrestling (classic SMW/WWF, Jim Cornette, and my deeply cursed WWE 2K25 Universe), my OCs who are realer to me than most people, witchcraft/spirit work/folk healing/moon rituals/grief magic, retro gaming, emotional overshares that read like journal entries from a possessed poet, fanfiction that makes people unwell at 2am, chaos, and the occasional Reddit food rabbit hole

My hobbies are: Writing fic that's 70% emotional breakdown, 20% worldbuilding, and 10% people getting railed in a meaningful way, hexing cults with sigils and sass, collecting music like a religion, drawing OCs, being a haunted glitter goblin with eyeliner and vengeance, building 48-year fanfiction universes with fully documented timelines and named children, going to work like a normal person and coming home a completely different entity

My fandoms are: Culture Club (I'm writing a massive AU called Colour By Numbers spanning 1978-2026, and a supernatural [not the show] fic called The Rhythm of the Hollow), Linkin Park (Bennoda forever), wrestling (SMW/WWF/WCW but mainly the universes in my head)

I'm looking for people who: are too weird for Reddit, too raw for Instagram, too smart for Twitter/X, overshare about their OCs like a religion, cry over character development, understand that Jon Moss deserved better, write long posts, and don't find it weird that I've named all the children in my fictional universe including the surprise baby

My posting schedule: Erratic. Sometimes a lot. Sometimes I vanish for three weeks and return with an entire AU timeline and a new OC

Dealbreakers: Racism, ableism, transphobia, homophobia, antisemitism, being a dick, Scientology apologists, anyone who thinks Mike Shinoda is evil because of an Instagram reel, "isn't wrestling fake?", "you still like Linkin Park?", and anti-Zionists/anti-Israel people.


Before adding me: I'm a trans man (he/him, they/them). Autistic and ADHD. I write mpreg unapologetically. I am a Zionist and tired of explaining what that actually means. Pro-AI. I smoke weed. I am extremely defensive of Jon Moss and will write essays about it. My AO3 is CampCornette69 and yes that's a wrestling reference. If you want an even more in-depth about me, click this link for my about post.

Allbingo and Crowdfunding

Mar. 30th, 2026 07:41 pm
ysabetwordsmith: Cartoon of me in Wordsmith persona (Default)
[personal profile] ysabetwordsmith posting in [site community profile] dw_community_promo
[community profile] allbingo provides a space for creative people to share their work, using bingo cards for inspiration.

[community profile] crowdfunding is a community for creators, patrons, and fans of cyberfunded creativity.

Further details below ...

Read more... )

battery day

Mar. 31st, 2026 10:34 am
tielan: (you broke it!)
[personal profile] tielan
I suspect my site is one of great frustration for these guys.

There is no space near our switchboard, so they have to make a stand-alone space for the battery and inverter to go. They have to dig down to make a base. There are tree roots like crazy.

It's not a nice site for installation - the house was not designed like modern houses: the land cleared of trees, the slab poured all over and everywhere. This house was built on enclosed brick footings - a base wall on clay that has lasted surprisingly long.

I'm probably also not the kind of homeowner they want to work for, someone who'll let them do their job instead of asking all kinds of questions and stuff.

Okay, and I'm stressed too rn.
penaltywaltz: (I'm A Mod)
[personal profile] penaltywaltz posting in [community profile] wipbigbang
WIP Big Bang/WIP Reverse Bang start in two days! Us mods are so excited, and we hope you are, too.

So, this round we're going to retire about 125 fandom banners of ones that either are being grouped under new banner to consolidate fandoms or are fandoms that never got much traction in the last few rounds. We are also going to add some new fandoms to the list and on that score, we would love suggestions! Here are the changes we are making:

New Fandoms

K-Pop Demon Hunters
The Amazing Digital Circus
Starfleet Academy
911 Nashville
Heated Rivalry
Game Changers book series (all characters not in HR)
Wonder Man
Thunderbolts*

Separated Fandoms:

Deltarune
Helluva Boss

Consolidated Fandoms:

The DCEU movies will be listed under a banner of the live action Justice League
Some of the single character MCU movies will be listed under the non-specific MCU banner (the old Avengers one will be used to list all the various MCU movie titles).

I will also try to do a banner for the comics X-Men as I have one for the live action movies going under my MCU listing of banners (since I'm renaming all the banners we're using and grouping them with the MCU thanks to them showing up in "Deadpool & Wolverine" as well as "Avengers: Doomsday") and would like input on whether I should do various X-Men comic titles or list X-Men who are not in the live action movies (or possibly both).

As we primarily do most of our advertising on Tumblr and I have over 350 fandom banners to use for that purpose (plus the 125 we're retiring), if you would like a banner for a specific fandom to use in advertising here on Dreamwidth or in Discord servers and in other places, let me know and I'll upload any banners I've got for it (or make one if I don't) and then once we have the sign-ups here on Dreamwidth you can link to them.

3/30/2026 Tilden Nature Area

Mar. 30th, 2026 04:24 pm
mrkinch: Erik holding fieldglasses in "Russia" (bins)
[personal profile] mrkinch
The Black-headed Grosbeaks have arrived! We think they're about a week early and were delighted to hear them. Their song is the most cheerful bird song I know, no minor phrases at all. Just wonderful. There were more Western Warbling Vireos than last week, and Orange-crowned, Wilson's, and Townsend's Warblers everywhere. Winter migrants still around were a few Hermit Thrushes and a skulking Fox Sparrow. The Anna's Hummingbird was on her nest; I didn't see additional bills but we didn't stay long by the Lake because a tree had broken off, landing on the bench where we usually sit for a while. I hope they clear it up pretty quickly. The list: )

Next arrivals in the Nature Area should be Swainson's Thrushes in about two weeks; sooner if they are early, too.

Revving Up LNP Delivery

Mar. 30th, 2026 03:19 pm
[syndicated profile] in_the_pipeline_feed

Now here’s something that I wouldn’t have guessed. As the world knows, lipid nanoparticles have been the key to getting mRNA vaccines to work, and they are useful for all other attempts to deliver RNA cargoes into cells and probably much besides. A huge amount of effort, time, and money has been put into trying to optimize them for these purposes - all sorts of different lipids and lipid mixes, close attention to size, morphology, and cargo loading, you name it.

But as this new paper notes, even with this, mRNA delivery can be rather spotty across different tissue types, for reasons that are still up for debate. The genetic background of the cells and tissues that youre trying to deliver to will clearly have an influence, but even going after what should be the same cell types you can see some real variation (and plenty of changes between in vitro and in vivo behavior). What’s not up for debate, sadly, is that if we’re going to have to just keep trying combinations of lipid carriers to get out of this problem, well, we could be at it a while: a four-component LNP could have up to ten billion potential combinations, given the number of candidates for each of those positions. 

The authors here note that culturing your target cells in different media leads to very different mRNA LNP outcomes. The standard cell media mixes are formulated to optimize cell growth in culture, and as such contain rather nonphysiological amounts of many nutrients. That was the impetus to develop human plasma-like medium (HPLM) to more closely mimic the in vivo situation. When they used that mix instead of the usual cell media, the authors saw the efficiency of the mRNA delivery drop sharply, which got them to thinking about the effects of all those extra components in the classic brews.

It turns out that the HPLM-grown cells show downregulation of several amino acid metabolic pathways (arginine, methione, and proline, for example), and the team hypothesized that this might have something to do with the impaired LNP uptake. Screening supplementation of individual amino acids in HPLM to bring their concentrations up to where they are in other media showed that extra methionine, arginine, and serine had a very significant effect on efficacy of mRNA delivery. Working on the concentrations of these in more detail, a mixture of 30x HPLM background in methionine, 10X arginine, and 30X serine performed well across the board, with five-to tenfold increases in delivery. Cells fed this mixture showed enrichment of endocytosis pathway proteins (but not those associated with endosomal escape, as far as could be seen). The clathrin-independent-carrier (CLIC) pathway seemed to be especially affected, and had already been flagged by other research as important for LNP success.

And convincingly, this amino acid supplementation idea worked in animals, showing greatly increased uptake of mRNA cargos both in model systems and with therapeutic cargos. And this worked not only for mRNA delivery, but for in vivo gene editing cargoes with CRISPR-Cas9 components as well. This is good news - it’s hard to see how anyone could have a problem with some extra amino acids being given along with the mRNA doses.

So it looks like the metabolic state of the target cells is indeed a key factor in hitting them with lipid nanoparticles, and that this can be easily modified with a cocktail of inexpensive, easily available and easily administered amino acids. I hope this idea gets some intensive scrutiny and that it works as well for others as it did here!

bah! and also, feh!

Mar. 30th, 2026 06:08 pm
musesfool: Zuko, brooding (why am i so bad at being good?)
[personal profile] musesfool
Even Nyquil couldn't keep my cough at bay all night. At least it's a productive cough? Bah. I feel like I am made entirely of mucus. How is there so much of it??? Plus I woke up with a fever this morning and again when I woke up from my nap just now.

I'm going to eat a bagel, poke around the internet, and then go back to bed and hope I feel better tomorrow. See you on the flip side!

*

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